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HAMILTON-T1. Intelligent transport ventilator

HAMILTON-T1

我们的转运专家!从新生儿到成人

  • 全功能 ICU 转运呼吸机
  • 适用于地面、空中和海上转运
  • 医院内和医院外
HAMILTON-T1
HAMILTON-T1

我们的转运专家! 从新生儿到成人

  • 全功能 ICU 转运呼吸机
  • 适用于地面、空中和海上病人转运
  • 医院内和医院外
HAMILTON-T1

适者生存! 在最苛刻的环境中

  • 温度范围:-15 至 +50°C
  • 防护等级:IP54
  • 最大海拔高度:7620 米
  • 冲击保护和防振的加固型外壳
  • 耐振、抗反射显示器
HAMILTON-T1

持续通气治疗。 使用和床旁相同的模式和设置

  • 容量靶向和压力控制通气模式
  • 带 ASV® 和 INTELLiVENT®-ASV 的适应性通气
  • 无创通气
  • 高流量鼻导管治疗
HAMILTON-T1

极度独立。 无压缩空气且由电池供电

  • 高性能涡轮
  • 一块集成电池和一块热插拔电池
  • 额外的低压氧接头
HAMILTON-T1

通信是关键。 改善连接

通信主板选项适用于:

  • 氧饱和度传感器和/或 CO2 传感器
  • 护士呼叫器
  • PDMS
  • HAMILTON-H900
  • RS232
HAMILTON-T1

保持联系。 无任何限制

在您的移动设备上通过 Hamilton Connect 应用访问呼吸数据。它提供了旨在促进和简化通气工作流程的工具。

HAMILTON-T1
病人接受 CPR

紧急救治! 在 CPR 时提供支持

如果您必须执行 CPR,则 CPR 通气自适应通气设置。其显示与情况相关的主要监测参数和曲线,并通过快速访问可预配置的设置、适当的报警和触发调节以及 CPR 计时器显示来支持您的工作流程。

Pie chart showing that 71% of air rescue organizations (in Germany, Austria, Switzerland, Italy, and Luxemburg) chose the HAMILTON‑T1 for their intensive care helicopter

The popular choice. For 71% of intensive care helicopters

As a transport ventilator for ambulances, helicopters, and more, the HAMILTON-T1 is a favorite for many rescue crews. According to the HOVER survey (Handover of ventilated Helicopter Emergency Services [HEMS] patients in the emergency roomA​) conducted online amongst air rescue organizations in Germany, Austria, Switzerland, Italy, and Luxemburg in 2019, 71% of those organizations chose the HAMILTON‑T1 for their intensive care helicopter (Hilbert-Carius, P., Struck, M.F., Hofer, V. et al. Nutzung des Hubschrauber-Respirators vom Landeplatz zum Zielort im Krankenhaus. Notfall Rettungsmed 23, 106–112 (2020)1​​).

Patient transport using a HAMILTON-T1

Don’t just meet standards. Exceed them

Ventilators suitable for pandemics and mass casualties must be versatile and meet various requirements. The HAMILTON-T1 meets or exceeds all requirements in the AARC Guidelines for Acquisition of Ventilators to Meet Demands for Pandemic Flu and Mass Casualty Incidents (www.aarc.org/wp-content/uploads/2020/03/ventilator-acquisition-guidelines.pdfB​).

Want to see more?
Explore the 3D model

Discover the HAMILTON-T1 from every angle and click on the hotspots to learn more.

For quick details

  • 标配
  • 选项
  • 不可用
病人组 成人/儿童、新生儿
外形尺寸(宽x深x高) 320 x 220 x 270 mm(呼吸机主机)
630 x 630 x 1380 mm(无手柄)
630 x 630 x 1433 mm(带手柄)
重量 6.5 kg(14.3 磅)
18.5 kg(40.8 磅)(含台车)
监视器尺寸和分辨率 214 mm(8.4 英寸)对角线
640 x 480 像素
可拆卸式监视器
电池运行时间 一块电池 4 小时
两块电池 8 小时
热插拔电池
气源 集成涡轮
O2 接头 DISS (CGA 1240) 或 NIST
连接 CO2/护士呼叫器/COM1,二氧化碳/SpO2/COM1,二氧化碳/SpO2/湿化器和 COM1,USB 端口,RJ-45 以太网端口
音量 43 dB(在正常运行情况下)
容量控制、流量控制
定量、适应性压力控制
智能通气 ASV®、INTELLiVENT®-ASV®(选项)
无创通气
高流量
肺力学指标可视化(动态肺)
病人呼吸机依赖性可视化
食道压测量
二氧化碳图
氧饱和度监测
肺复张性评估和肺复张 (P/V Tool Pro)
人机同步 (IntelliSync+)
CPR 通气
Hamilton Connect 模块
远程连接至 HAMILTON-H900 湿化器
集成 IntelliCuff 气囊压力控制器
集成气动雾化器
集成 Aerogen 雾化器
与 Sedaconda ACD-S 麻醉剂输送系统的兼容性
使命召唤;HAMILTON-T1 军用型

军用呼吸机。

使命召唤

暴露于极端环境意味着军用呼吸机必须满足非常特殊的要求。这是 HAMILTON-T1 的用途所在。

For your patients

Intelligent ventilation solutions at a glance

ASV® - Adaptive Support Ventilation®。 适用于全天候适应

根据病人的肺力学指标和呼吸用力,ASV 通气模式每天 24 时从插管到拔管连续调整每次呼吸时的呼吸频率、潮气量和吸气时间。

INTELLiVENT®-ASV。 适用于床旁辅助

INTELLiVENT-ASV 智能通气模式持续调整病人的通气和氧合状态。

它根据临床医生设定的目标值和病人的生理输入设置分钟通气量、PEEP 和氧浓度。

集成雾化器。 适用于额外治疗

集成气动雾化器完全与吸气和呼气时间同步。

集成同步 Aerogen 雾化系统作为一个选配件提供 (并非在所有市场均有提供a​, 仅适用于 HAMILTON-C6/G5/S1b​)。

输送药物气溶胶粒子的细水雾有助于您恢复支气管痉挛、提高通气效率和减少高碳酸血症 (Dhand R. New frontiers in aerosol delivery during mechanical ventilation.Respir Care.2004;49(6):666-677.100​, Waldrep JC, Dhand R. Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation.Curr Drug Deliv.2008;5(2):114-119. doi:10.2174/156720108783954815101​)。

容积二氧化碳图。 适用于 CO2ntrol 狂热爱好者

近端流速和二氧化碳测量使我们的呼吸机能生成最新的容积二氧化碳图,为评估通气质量和新陈代谢活动提供生要依据。

呼吸机状态面板。 适用于准备撤机者

通气状态面板显示与病人的呼吸机依赖性相关的六个参数,包括氧合状态、CO2 清除状态和病人活动。

各栏中上下移动的浮动指示器显示给定参数的当前值。

远程湿化器访问。 便于使用

通过独特的呼吸机连接选项可以直接从呼吸机的显示屏上操作 HAMILTON-H900 湿化器(HAMILTON-H900 不适用于转运。e)。您可以访问所有控件、监测参数和报警,并根据需要予以调节。

湿化器也可以根据所选的通气模式自动选择湿化模式(有创、无创或高流量)。

高流量鼻导管治疗。 适用于通气专家

高流量鼻导管治疗(也称为高流量氧疗。此术语可与高流量鼻导管治疗互换使用f​)可作为我们所有呼吸机上的一个选项提供。只需简单几步,即可更改界面,并且使用同一装置和呼吸管路来满足病人的治疗需求。

说话瓣膜。 适用于“话匣子”

说话瓣膜选项让气管切开的病人说话,而且允许他们甚至在接受通气治疗时吞咽。

调节呼吸机的监测、触发和报警管理,以在压力控制模式 (PCV+, SPONT, PSIMV+) 下与说话瓣膜兼容。

快速撤机。 适用于独立思考者

快速撤机是 INTELLiVENT-ASV 模式的一个功能,其可提供对病人状况的持续动态监测和控制,从而评估病人是否适于拔管。

动态肺面板。 使用目视监测者

动态肺面板向您显示下列重要监测数据的实时图表视图:

  • 顺应性和阻力
  • 病人触发
  • 氧饱和度
  • 脉率

可配置的环图和趋势图。 适用于统计员

呼吸机可根据所选的监测参数组合显示动态环图。有了趋势图功能,您可以看到针对您选择的监测参数和时间框所显示的趋势数据。 

设备持续将监测参数保存在其存储器中,即使在待机时也不停止。

脉搏血氧计。 适用于氧饱和度热衷者

氧饱和度选项提供集成无创氧饱和度测量,数据方便地显示在您的呼吸机上。

我们还提供氧饱和度传感器的全面组合方案。

高性能无创通气。 适用于面罩佩戴者

无创通气模式提供压力支持流速切换的自主呼吸(NIV 和 NIV-ST 模式)和压力控制时间切换的指令呼吸 (NIV-ST)。

与使用压缩空气的呼吸机相比,我们的涡轮驱动呼吸机能够提供更高的峰值流量。这就保证了即便漏气严重也具有最佳性能。

nCPAP 模式。 适用于小病人

nCPAP 模式的设计使您仅需设置期望的持续气道正压。之后,根据病人状况和潜在漏气调整流速。这就防止了意外峰值压力的产生,保证了高效的漏气补偿,并帮助减少了氧气消耗。由于压力测量灵敏度很高,流速的调整非常迅速。

Intermountain Life Flight Rega - Swiss Air Ambulance LifeLink III

Intermountain Life Flight

美国犹他州盐湖城

Intermountain Life Flight 是犹他州领先的空中救援服务。自 1978 年开始计划以来,我们信守承诺,通过直升机、固定翼和地面救护车为患者提供卓越护理。

Rega - Swiss Air Ambulance

Zürich, Schweiz

Swiss Air-Rescue 是瑞士空中救援的非营利私人基金会,由瑞士救生协会成员于 1952 年成立,总部设在苏黎世机场。

阅读用户报告

LifeLink III

美国明尼苏达州布卢明顿市

Life Link III 运营着遍布明尼苏达州和威斯康星州的九个直升机基地。全天候提供直升机和飞机服务,提供现场应急响应和机构间转运。

For you

Breathing circuit set, coaxial

Preassembled. And ready to use

Our preassembled breathing circuit sets include the essential consumables to operate the ventilator, conveniently packaged in one single bag.

All our essential consumables are specially developed for Hamilton Medical ventilators with guaranteed manufacturer quality.

Automation; Hand turns knob button clockwise

Less knob-turning. More adaptations to your patient

To manage ventilation you usually have to set multiple parameters, such as pressure, volume, inspiratory and expiratory triggers, cuff pressure, and more. And each time your patient's condition changes, you have to make one or even several readjustments.

To simplify this process and reduce the knob-turning, we have created a range of solutions:

Adaptive Support Ventilation (ASV) is a ventilation mode that provides continuous adaptation of respiratory rate, tidal volume, and inspiratory time, depending on the patient’s lung mechanics and effort. ASV has been shown to shorten the duration of mechanical ventilation in various patient populations with fewer manual settings (Kirakli C, Naz I, Ediboglu O, Tatar D, Budak A, Tellioglu E. A randomized controlled trial comparing the ventilation duration between adaptive support ventilation and pressure assist/control ventilation in medical patients in the ICU. Chest. 2015;147(6):1503-1509. doi:10.1378/chest.14-25992​, Tam MK, Wong WT, Gomersall CD, et al. A randomized controlled trial of 2 protocols for weaning cardiac surgical patients receiving adaptive support ventilation. J Crit Care. 2016;33:163-168. doi:10.1016/j.jcrc.2016.01.0183​, Zhu F, Gomersall CD, Ng SK, Underwood MJ, Lee A. A randomized controlled trial of adaptive support ventilation mode to wean patients after fast-track cardiac valvular surgery. Anesthesiology. 2015;122(4):832-840. doi:10.1097/ALN.00000000000005894​).

Conventional solutions for cuff pressure management require you to monitor and adjust cuff pressure by hand.

IntelliCuff secures your patient’s airway (Chenelle CT, Oto J, Sulemanji D, Fisher DF, Kacmarek RM. Evaluation of an automated endotracheal tube cuff controller during simulated mechanical ventilation. Respir Care. 2015;60(2):183-190. doi:10.4187/respcare.033875​) by continuously measuring and automatically maintaining the set cuff pressure for adult, pediatric, and neonatal patients.

Professional interacting with touch-screen

Help is near! On-screen troubleshooting

Whenever there is a problem, the ventilator alerts you using the alarm lamp, sound, and message bar.

The on-screen help offers you suggestions on how to resolve the alarm.

Professionals looking into Hamilton Medical e-learnings

Get the hang of it! Learning paths and educational content

Our online Academy offers easy-to-follow learning paths to familiarize you with Hamilton Medical products and technologies as quickly as possible.

Ralf Huth 博士 Trisha Degoyer Thomas Burren

客户评语

我们使用 HAMILTON-T1 为院内转运和院外转运病人通气。保证病人转运过程中的通气质量与床头通气质量等同。

Ralf Huth 博士

跨学科儿科 ICU 高级医生
Center for Pediatrics and Adolescent Medicine,德国美因茨

客户评语

能够将 nCPAP 与 HAMILTON‑T1 结合使用是我们的一大优点。某些幼儿转运时不再需要插管。

Trisha Degoyer

Life Flight 新生儿呼吸科护士
Intermountain Life Flight,美国犹他州盐湖城

客户评语

HAMILTON‑T1 呼吸机小巧而紧凑,但仍具备常频 ICU 呼吸机的所有特点。

Thomas Burren

Rega Jet 护士长
Rega - Swiss Air Rescue,瑞士苏黎世

For the future

Illustration of a compass pointing towards the future

Constant evolution. Expanding your ventilator’s capabilities

We are constantly working on further evolving our products. New features are added and existing features improved to ensure you always have access to the latest ventilation technology over your ventilator’s lifetime.

How we keep your ventilator up-to-date
Hamilton ventilation family Hamilton ventilation family

Know one, know them all. A universal user interface

Whether it is in the ICU, in the MRI suite, or during transport, the user interface of all Hamilton Medical ventilators works in the same way.

Our Ventilation Cockpit integrates complex data into intuitive visualizations.

For the complete solution

Fully integrated accessories

We develop our accessories for the highest possible patient safety and ease of use in mind. Whenever possible, we integrate them with our ventilators to simplify operation of the complete ventilator system.

Our consumables

All Hamilton Medical Originals are designed for optimal performance with Hamilton Medical ventilators. To ensure maximum user satisfaction and patient safety, we strive for the highest quality and safety standards.
员工照片

与我们的专家交流。 讨论您的需求

我们的通气极客团队很乐意帮助您选择最适合您临床护理环境的通气设备,并帮助您实现治疗目标。获取个性化报价或安排电话回访,了解更多信息。

参考文献

  1. 1. Hilbert-Carius, P., Struck, M.F., Hofer, V. et al. Nutzung des Hubschrauber-Respirators vom Landeplatz zum Zielort im Krankenhaus. Notfall Rettungsmed 23, 106–112 (2020).
  2. 2. Kirakli C, Naz I, Ediboglu O, Tatar D, Budak A, Tellioglu E. A randomized controlled trial comparing the ventilation duration between adaptive support ventilation and pressure assist/control ventilation in medical patients in the ICU. Chest. 2015;147(6):1503-1509. doi:10.1378/chest.14-2599
  3. 3. Tam MK, Wong WT, Gomersall CD, et al. A randomized controlled trial of 2 protocols for weaning cardiac surgical patients receiving adaptive support ventilation. J Crit Care. 2016;33:163-168. doi:10.1016/j.jcrc.2016.01.018
  4. 4. Zhu F, Gomersall CD, Ng SK, Underwood MJ, Lee A. A randomized controlled trial of adaptive support ventilation mode to wean patients after fast-track cardiac valvular surgery. Anesthesiology. 2015;122(4):832-840. doi:10.1097/ALN.0000000000000589

 

  1. 5. Chenelle CT, Oto J, Sulemanji D, Fisher DF, Kacmarek RM. Evaluation of an automated endotracheal tube cuff controller during simulated mechanical ventilation. Respir Care. 2015;60(2):183-190. doi:10.4187/respcare.03387
  2. 100. Dhand R. New frontiers in aerosol delivery during mechanical ventilation. Respir Care. 2004;49(6):666-677.
  3. 101. Waldrep JC, Dhand R. Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation. Curr Drug Deliv. 2008;5(2):114-119. doi:10.2174/156720108783954815

脚注

  • A. 接受通气治疗的直升机紧急医疗服务 [HEMS] 的急诊室病人的转运交接
  • B. https://www.aarc.org/wp-content/uploads/2020/03/ventilator-acquisition-issue-paper.pdf
  • D. HAMILTON-H900 不适用于转运

 

  • a. 并非在所有市场均有提供
  • b. 仅适用于 HAMILTON-C6/G5/S1
  • f. 也称为高流量氧疗。此术语可与高流量鼻导管治疗互换使用。

Nutzung des Hubschrauber-Respirators vom Landeplatz zum Zielort im Krankenhaus Sekundäranalyse der HOVER-Umfrage zu beatmeten Notfallpatienten in der Luftrettung

Hilbert-Carius, P., Struck, M.F., Hofer, V. et al. Nutzung des Hubschrauber-Respirators vom Landeplatz zum Zielort im Krankenhaus. Notfall Rettungsmed 23, 106–112 (2020).

A randomized controlled trial comparing the ventilation duration between adaptive support ventilation and pressure assist/control ventilation in medical patients in the ICU.

Kirakli C, Naz I, Ediboglu O, Tatar D, Budak A, Tellioglu E. A randomized controlled trial comparing the ventilation duration between adaptive support ventilation and pressure assist/control ventilation in medical patients in the ICU. Chest. 2015;147(6):1503-1509. doi:10.1378/chest.14-2599



BACKGROUND

Adaptive support ventilation (ASV) is a closed loop mode of mechanical ventilation (MV) that provides a target minute ventilation by automatically adapting inspiratory pressure and respiratory rate with the minimum work of breathing on the part of the patient. The aim of this study was to determine the effect of ASV on total MV duration when compared with pressure assist/control ventilation.

METHODS

Adult medical patients intubated and mechanically ventilated for > 24 h in a medical ICU were randomized to either ASV or pressure assist/control ventilation. Sedation and medical treatment were standardized for each group. Primary outcome was the total MV duration. Secondary outcomes were the weaning duration, number of manual settings of the ventilator, and weaning success rates.

RESULTS

Two hundred twenty-nine patients were included. Median MV duration until weaning, weaning duration, and total MV duration were significantly shorter in the ASV group (67 [43-94] h vs 92 [61-165] h, P = .003; 2 [2-2] h vs 2 [2-80] h, P = .001; and 4 [2-6] days vs 4 [3-9] days, P = .016, respectively). Patients in the ASV group required fewer total number of manual settings on the ventilator to reach the desired pH and Paco2 levels (2 [1-2] vs 3 [2-5], P < .001). The number of patients extubated successfully on the first attempt was significantly higher in the ASV group (P = .001). Weaning success and mortality at day 28 were comparable between the two groups.

CONCLUSIONS

In medical patients in the ICU, ASV may shorten the duration of weaning and total MV duration with a fewer number of manual ventilator settings.

TRIAL REGISTRY

ClinicalTrials.gov; No.: NCT01472302; URL: www.clinicaltrials.gov.

A randomized controlled trial of 2 protocols for weaning cardiac surgical patients receiving adaptive support ventilation.

Tam MK, Wong WT, Gomersall CD, et al. A randomized controlled trial of 2 protocols for weaning cardiac surgical patients receiving adaptive support ventilation. J Crit Care. 2016;33:163-168. doi:10.1016/j.jcrc.2016.01.018



PURPOSE

This study aims to compare the effectiveness of weaning with adaptive support ventilation (ASV) incorporating progressively reduced or constant target minute ventilation in the protocol in postoperative care after cardiac surgery.

MATERIAL AND METHODS

A randomized controlled unblinded study of 52 patients after elective coronary artery bypass surgery was carried out to determine whether a protocol incorporating a decremental target minute ventilation (DTMV) results in more rapid weaning of patients ventilated in ASV mode compared to a protocol incorporating a constant target minute ventilation.

RESULTS

Median duration of mechanical ventilation (145 vs 309 minutes; P = .001) and intubation (225 vs 423 minutes; P = .005) were significantly shorter in the DTMV group. There was no difference in adverse effects (42% vs 46%) or mortality (0% vs 0%) between the 2 groups.

CONCLUSIONS

Use of a DTMV protocol for postoperative ventilation of cardiac surgical patients in ASV mode results in a shorter duration of ventilation and intubation without evidence of increased risk of adverse effects.

A randomized controlled trial of adaptive support ventilation mode to wean patients after fast-track cardiac valvular surgery.

Zhu F, Gomersall CD, Ng SK, Underwood MJ, Lee A. A randomized controlled trial of adaptive support ventilation mode to wean patients after fast-track cardiac valvular surgery. Anesthesiology. 2015;122(4):832-840. doi:10.1097/ALN.0000000000000589



BACKGROUND

Adaptive support ventilation can speed weaning after coronary artery surgery compared with protocolized weaning using other modes. There are no data to support this mode of weaning after cardiac valvular surgery. Furthermore, control group weaning times have been long, suggesting that the results may reflect control group protocols that delay weaning rather than a real advantage of adaptive support ventilation.

METHODS

Randomized (computer-generated sequence and sealed opaque envelopes), parallel-arm, unblinded trial of adaptive support ventilation versus physician-directed weaning after adult fast-track cardiac valvular surgery. The primary outcome was duration of mechanical ventilation. Patients aged 18 to 80 yr without significant renal, liver, or lung disease or severe impairment of left ventricular function undergoing uncomplicated elective valve surgery were eligible. Care was standardized, except postoperative ventilation. In the adaptive support ventilation group, target minute ventilation and inspired oxygen concentration were adjusted according to blood gases. A spontaneous breathing trial was carried out when the total inspiratory pressure of 15 cm H2O or less with positive end-expiratory pressure of 5 cm H2O. In the control group, the duty physician made all ventilatory decisions.

RESULTS

Median duration of ventilation was statistically significantly shorter (P = 0.013) in the adaptive support ventilation group (205 [141 to 295] min, n = 30) than that in controls (342 [214 to 491] min, n = 31). Manual ventilator changes and alarms were less common in the adaptive support ventilation group, and arterial blood gas estimations were more common.

CONCLUSION

Adaptive support ventilation reduces ventilation time by more than 2 h in patients who have undergone fast-track cardiac valvular surgery while reducing the number of manual ventilator changes and alarms.

Evaluation of an automated endotracheal tube cuff controller during simulated mechanical ventilation.

Chenelle CT, Oto J, Sulemanji D, Fisher DF, Kacmarek RM. Evaluation of an automated endotracheal tube cuff controller during simulated mechanical ventilation. Respir Care. 2015;60(2):183-190. doi:10.4187/respcare.03387



BACKGROUND

Maintaining endotracheal tube cuff pressure within a narrow range is an important factor in patient care. The goal of this study was to evaluate the IntelliCuff against the manual technique for maintaining cuff pressure during simulated mechanical ventilation with and without movement.

METHODS

The IntelliCuff was compared to the manual technique of a manometer and syringe. Two independent studies were performed during mechanical ventilation: part 1, a 2-h trial incorporating continuous mannikin head movement; and part 2, an 8-h trial using a stationary trachea model. We set cuff pressure to 25 cm H2O, PEEP to 10 cm H2O, and peak inspiratory pressures to 20, 30, and 40 cm H2O. Clinical importance was defined as both statistically significant (P<.05) and clinically significant (pressure change [Δ]>10%).

RESULTS

In part 1, the change in cuff pressure from before to after ventilation was clinically important for the manual technique (P<.001, Δ=-39.6%) but not for the IntelliCuff (P=.02, Δ=3.5%). In part 2, the change in cuff pressure from before to after ventilation was clinically important for the manual technique (P=.004, Δ=-14.39%) but not for the IntelliCuff (P=.20, Δ=5.65%).

CONCLUSIONS

There was a clinically important drop in manually set cuff pressure during simulated mechanical ventilation in a stationary model and an even larger drop with movement, but this was significantly reduced by the IntelliCuff in both scenarios. Additionally, we observed that cuff pressure varied directly with inspiratory airway pressure for both techniques, leading to elevated average cuff pressures.

New frontiers in aerosol delivery during mechanical ventilation.

Dhand R. New frontiers in aerosol delivery during mechanical ventilation. Respir Care. 2004;49(6):666-677.

The scientific basis for inhalation therapy in mechanically-ventilated patients is now firmly established. A variety of new devices that deliver drugs to the lung with high efficiency could be employed for drug delivery during mechanical ventilation. Encapsulation of drugs within liposomes could increase the amount of drug delivered, prolong the effect of a dose, and minimize adverse effects. With improved inhalation devices and surfactant formulations, inhaled surfactant could be employed for several indications in mechanically-ventilated patients. Research is unraveling the causes of some disorders that have been poorly understood, and our improved understanding of the causal mechanisms of various respiratory disorders will provide new applications for inhaled therapies.

Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation.

Waldrep JC, Dhand R. Advanced nebulizer designs employing vibrating mesh/aperture plate technologies for aerosol generation. Curr Drug Deliv. 2008;5(2):114-119. doi:10.2174/156720108783954815

Recent technological advances and improved nebulizer designs have overcome many limitations of jet nebulizers. Newer devices employ a vibrating mesh or aperture plate (VM/AP) for the generation of therapeutic aerosols with consistent, increased efficiency, predominant aerosol fine particle fractions, low residuals, and the ability to nebulize even microliter volumes. These enhancements are achieved through several different design features and include improvements that promote patient compliance, such as compact design, portability, shorter treatment durations, and quiet operation. Current VM/AP devices in clinical use are the Omron MicroAir, the Nektar Aeroneb, and the Pari eFlow. However, some devices are only approved for use with specific medications. Development of "smart nebulizers" such as the Respironics I-neb couple VM technologies with coordinated delivery and optimized inhalation patterns to enhance inhaled drug delivery of specialized, expensive formulations. Ongoing development of advanced aerosol technologies should improve clinical outcomes and continue to expand therapeutic options as newer inhaled drugs become available.