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 Consumables

Nebulization. High-performance aerosol drug delivery

Aerogen nebulizer with HAMILTON-H900 Aerogen nebulizer with HAMILTON-H900

The Aerogen nebulizer. Inhaled medication where it's needed

We offer nebulization solutions from Aerogen, the world’s leading manufacturer and distributor of high-performance technology for delivering aerosol medication treatment.

Aerogen Solo

Aerogen Solo. Nebulizer for single patient use

Vibrating mesh technology produces consistent droplet-sized particles:

  • Improved medication delivery compared to a jet nebulizer observed in a simulated lung model (Ari A, Atalay OT, Harwood R, Sheard MM, Aljamhan EA, Fink JB. Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care. 2010;55(7):845-851. 1​)
  • No added flow required
  • Suitable for physician-prescribed medications for inhalation
  • Can be powered by the optional inbuilt controller in HAMILTON-C6 and HAMILTON-G5/S1 ventilators, or by the Aerogen Pro-X Controller or Aerogen USB Controller
Aerogen Pro-X Controller

Aerogen Pro-X Controller. Your portable power source

Throughout the hospital, the Pro-X Controller provides power for Aerogen technologies in a portable device. 

  • Powers the Aerogen Solo
  • 30-minute and continuous mode options
  • Internal 45-minute battery
Aerogen USB controller

Aerogen USB Controller. Power from any USB port

The slimline Aerogen USB controller can be used to power the Aerogen Solo from the USB port on your ventilator (For US users, the Aerogen USB Controller should only be operated from mains power using the Aerogen USB Controller AC/DC Adapter.A​).

  • Powers the Aerogen Solo
  • Quick and easy to set up
  • 30-minute and 6-hour mode options
e-Catalog

For more information

Document
Nebulizer positioning guidelines
English | 0.81 MB | ELO2020-124-TW.01
Document
Aerogen Clinical whitepaper
English | 3.44 MB
Document
Aerogen Solo/Aerogen Pro Instructions for use
English | 1.13 MB | 627128.02
Show more

Footnotes

  • A. For US users, the Aerogen USB Controller should only be operated from mains power using the Aerogen USB Controller AC/DC Adapter.

References

  1. 1. Ari A, Atalay OT, Harwood R, Sheard MM, Aljamhan EA, Fink JB. Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care. 2010;55(7):845-851.

Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation.

Ari A, Atalay OT, Harwood R, Sheard MM, Aljamhan EA, Fink JB. Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care. 2010;55(7):845-851.



BACKGROUND

The effectiveness of aerosol drug delivery during mechanical ventilation is influenced by the patient, ventilator, and nebulizer variables. The impact of nebulizer type, position on the ventilator circuit, and bias flow on aerosol drug delivery has not been established for different age populations.

OBJECTIVE

To determine the influence of nebulizer position and bias flow with a jet nebulizer and a vibrating-mesh nebulizer on aerosol drug delivery in simulated and mechanically ventilated pediatric and adult patients.

METHOD

Albuterol sulfate (2.5 mg) was nebulized with a jet nebulizer and a vibrating-mesh nebulizer, using simulated pediatric and adult lung models. The 2 nebulizer positions were: (1) jet nebulizer placed 15 cm from the Y-piece adapter, and vibrating-mesh nebulizer attached directly to the Y-piece; and (2) jet nebulizer placed prior to the heated humidifier with 15 cm of large-bore tubing, and vibrating-mesh nebulizer positioned at an inlet to the humidifier. A ventilator with a heated humidifier and ventilator circuit was utilized in both lung models. The adult ventilator settings were V(T) 500 mL, PEEP 5 cm H2O, respiratory rate 20 breaths/min, peak inspiratory flow 60 L/min, and descending ramp flow waveform. The pediatric ventilator settings were V(T) 100 mL, PEEP 5 cm H2O, respiratory rate 20 breaths/min, inspiratory time 1 s. We tested bias flows of 2 and 5 L/min. The adult and pediatric lung models used 8-mm and 5-mm inner-diameter endotracheal tubes, respectively. Each experiment was run 3 times (n = 3). The albuterol sulfate was eluted from the filter and analyzed via spectrophotometry (276 nm).

RESULTS

Nebulizer placement prior to the humidifier increased drug delivery with both the jet nebulizer and the vibrating-mesh nebulizer, with a greater increase with the vibrating-mesh nebulizer. Higher bias flow reduced drug delivery. Drug delivery with the vibrating-mesh nebulizer was 2-4-fold greater than with the jet nebulizer at all positions (P < .05) in both lung models.

CONCLUSION

During simulated mechanical ventilation in pediatric and adult models, bias flow and nebulizer type and position impact aerosol drug delivery.